The exponential growth of human population and their activity in the last decades have negative effects on biodiversity. The main objective of this review was to present a compilation of works on causes of mortality of native wildlife in Europe, in the last decades linked to human activity. Here, a total of 130 peer-reviewed publications were reviewed for the period between 1942 to 2017 from thirty-eight countries. Sixty-five percent of the studies were focused on bird’s species. Our results showed that the main cause of mortality was due to traumatic origin, particularly collision with infrastructures and motor vehicles. Based on the papers analysed in the present study, it is possible to conclude that human development and its anthropogenic pressures have a negative effect in some species of wildlife, while the potential effects on the vast majority of other species are still unknown. This study provided an insight into the effects of the different anthropogenic pressures on the European fauna, giving valuable information on its main threats and raising important questions on rehabilitation management practices.